Selection of hydrotropes for enhancing the solubility of artemisinin in aqueous solutions

Artemisinin is an antimalarial substance very sparingly soluble in water. In the attempt to identify environmental-friendly and non-toxic aqueous-based solvents extract it from Artemisia annua L., solubility of artemisinin aqueous solutions different hydrotropes was measured at 303.2 K, for hydrotrope concentrations up 5 M. The ability studied enhancing increases following order: Na[N(CN)2] < Na[SCN] [Chol][Van] [Chol][Gal] [N4,4,4,4]Cl [Chol][Sal] [P4,4,4,4]Cl Na[Sal], with Na[Sal] allowing increase 750 fold compared pure COSMO-RS model experimental Kamlet-Taft solvatochromic parameters were applied connect enhancement solvent properties. At low concentration, decreasing difference between Apolar Factors artemisinin, while higher hydrogen-bond acceptor character seems have impact on enhancement. Even if some mechanistic understanding still unfold, quantitatively empirical correlations concentration show high accuracy. particular, 93% change could be explained using two combined (?? ?*2) as explaining variables.